Kelsey Grammer reveals first details of his Frasier sequel - and Frasier's change of profession

• Kelsey Grammer responds to Frasier return rumours: "it's in the early stages"
• Frasier actor John Mahoney dies aged 77
• Watch full series of Patrick Melrose, Save Me and In the Long Run for FREE on RadioTimes.com

During an appearance on The Late Late Show with James Corden, Grammer explained: "The first principle is that it is a different story, basically. The same group of characters, but in a different setting. Something has changed in their lives."

Acknowledging the death of his character's on-screen father he added: "Certainly, John Mahoney died over a year ago and we would probably deal with that a little bit, dad being gone."

Grammer is hoping for a series which will move the story on, and make it "the third act of Frasier rather than trying to pick it up, like Will & Grace did, right where they were."

"He's past the radio show," he said. "He might be an art dealer. He might be a professor. We don’t know yet.” The actor also suggested that Frasier may still be living in Chicago, where he moved at the very end of the last episode, leaving his friends behind in Seattle.

The original series of Frasier – itself a spin-off from classic US sitcom Cheers –charted the lives of the highfalutin radio therapist, his up-tight psychiatrist brother and their dad, a down to earth retired cop with very little in common with his sons.

It ran from 1993 to 2004, and earned a massive 37 Primetime Emmy Awards.

Sign up for the free RadioTimes.com newsletter