***Spoiler warning for the US pace of Grey's Anatomy season 20, which aired its winter finale on Thursday 21st December 2024.***

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At long last, Grey's Anatomy season 21 has aired its winter premier in the US on ABC following some dramatic developments.

There have been some major changes occurring to the cast of Grey's Anatomy with two regular cast members departing the series for good in these episodes.

So, what's happened in Gery's this season?

Read on for everything you need to know about Grey's Anatomy season 21.

Grey's Anatomy season 21 release date

It has been confirmed that Grey's Anatomy season 21 began airing in the US on ABC at 10pm ET/PT on Thursday 26th September, with new episodes airing weekly at the same time from then on.

Episodes will also become available to watch on Hulu the day after they broadcast on ABC.

The episodes are being released a week behind the US air pace at the moment on Disney+ in the UK.

The series won't be impacted by industry strikes this time around, so we should expect a full-length season.

Who stars in Grey's Anatomy season 21?

The main cast will see two departures in the next season. Actor Jake Borelli will return for an exit storyline for long-running character Dr Levi Schmitt, while actress Midori Francis will also be leaving the show following an exit storyline for Dr Mika Yasuda, making her the first of the new generation of interns to leave the series.

Both are expected to appear in multiple episodes before they leave next season.

Kim Raver as Dr Teddy Altman and Kevin McKidd as Dr Owen Hunt stand in outdoor wear in a forest setting for Grey's Anatomy.
Dr Teddy Altman (Kim Raver, left) and Dr Owen Hunt (Kevin McKidd, right) lost their jobs in the finale - but will be back! Disney/Anne Marie Fox

Deadline has also reported that a cost-cutting move will likely see episodic appearances for series veterans reduced in a bid to lower costs, which appears to be the reason for Borelli's exit too.

It's also been announced that Scott Speedman's Dr Nick Marsh has closed a deal to appear in more season 21 episodes, meaning that things could be getting rather serious for him and Meredith.

Natalie Morales (Dr Monica Beltran) has also joined the season 21 recurring cast, having guest starred in season 20 as the new paediatric surgeon.

Additionally, we can likely expect returns for recurring characters including Debbie Allen as Dr Catherine Fox and Jaicy Elliot as Dr Taryn Helm.

According to Deadline, it is expected that Jason George will return to a more prominent role in the show as Ben following the end of the spin-off series Station 19 and Dr Warren's renewed interest in medicine. It has been announced that he will return in a series regular capacity so we'll have to wait and see what's in store for him now.

Adding to the hospital's roster, there is also a cast addition of Grey Sloan's new chaplain James, who will be openly gay, and played by Michael Thomas Grant.

As per ABC's character description (via Deadline): "James joins Grey Sloan as the hospital’s openly gay Episcopal chaplain. He holds a special place in his heart for his younger patients, and his warmth, training and spirituality make him comfortable and confident in any situation.

"In his personal life, James finds himself at a crossroads where he is open to love and taking great leaps of faith."

In the guest star stakes, it's also been confirmed that Kali Rocha will be reprising her role as season 2 character Sydney Heron, 17 years after she was last seen in the medical drama. Set to appear in three episodes of the new season, details about her upcoming character arc remain under wraps for now.

Floriana Lima will also join the cast as a childhood friend of Owen (Kevin McKidd) and Megan Hunt’s (Abigail Spencer), and is set to be introduced in an early October episode.

While we don't know in what capacity, a new promo for the series has also teased the return of Jackson Avery (Jesse Williams).

Grey's Anatomy season 21 episodes

Jake Borelli as Dr Levi Schmitt in pink scrubs treating a baby in Grey's Anatomy.
Dr Levi Schmitt faces tough choices this season. ABC/Disney/Tina Thorpe

Here are details on the episodes of Grey's Anatomy this season.

  1. If Walls Could Talk - After firing some of Grey Sloan’s best, Catherine continues to interfere with Meredith and Amelia’s research. Accidents at a climate change protest bring unique cases to the hospital, and Bailey encounters a blast from the past.
  2. Take Me to Church - Meredith and Catherine continue to disagree, and Meredith confides in Bailey for support. Richard, Winston and Lucas spend the day outside of the hospital, and Blue deals with a relationship from his past. Levi meets the new hospital chaplain.
  3. I Can See Clearly Now - Simone and Lucas work to balance their relationship while competing to assist on an awake kidney transplant. Teddy offers Amelia a new opportunity, and Ben’s interview doesn’t go as planned. Meredith’s secret causes tension with Richard.
  4. This One's for the Girls - Mika struggles with a life-altering personal matter. Meanwhile, Bailey and Ben navigate their personal and professional roles, while Levi finds a connection in an unlikely place. Jo and Link get surprising news.
  5. You Make My Heart Explode - During a high-stress day at Grey Sloan Memorial, the fates of a patient in critical condition and a helicopter-bound medical team hang in the balance. Teddy and Owen work on their marriage, while Bailey, Blue and Link treat a hospital employee.
  6. Night Moves - Teddy and Owen plan a date night that gets derailed in more ways than one, while Jo struggles to do it all at home. Mika adds more to her plate to make up for taking time off to be with her sister, and Levi is faced with a monumental decision.
  7. If You Leave - The doctors at Grey Sloan must put aside their emotions under intense circumstances. Levi asks James a shocking question that could impact their future.
  8. Drop It Like It's Hot - In the midst of a deadly heat wave, the team at Grey Sloan struggles to keep up with an overwhelming amount of patients. Amelia and Winston face a challenging surgery, while Jo and Lucas run an errand for the hospital that takes an unexpected turn.

What will happen in Grey's Anatomy season 21?

Debbie Allen as a stern-looking Dr Catherine Fox seated at a boardroom table in Grey's Anatomy season 20
Dr Catherine Fox (Debbie Allen) was on one power trip in the Grey's Anatomy season 20 finale. Disney/Anne Marie Fox

Well, there are a number of plot points to continue following the finale of season 20.

Dr Catherine Fox went on a firing spree following multiple clashes, cutting ties with Dr Meredith Grey over her secret Alzheimer's research and then with Meredith's accomplices Dr Amelia Shepherd and Dr Teddy Altman - the latter of whom was fired as Chief of Surgery. Dr Owen Hunt was also fired when he stood up for Teddy when Catherine tried to drop her from a trauma response team to a wildfire.

Meanwhile, the interns were also in a mutiny over the harsh decision made by Dr Fox against Dr Lucas Adams, which did not seem to bother Dr Fox until she faced the potential resignation of Dr Miranda Bailey!

Elsewhere, Dr Richard Webber had also been questioning his career after having a major shaky period following the near-breaking of his sobriety.

Chandra Wilson smiles as Dr Miranda Bailey in a white doctor coat in Grey's Anatomy season 20.
Dr Miranda Bailey (Chandra Wilson) took a stand against Catherine. Disney/Anne Marie Fox

Dr Levi Schmitt also considered his career future as he aimed to get on a pediatric medicine fellowship and we know his exit is imminent...

Plus, Dr Jo Wilson discovered she was pregnant with Dr Atticus 'Link' Lincoln's baby - will the pair's family continue to run smoothly?

Finally, romance is in the air for divorcé Dr Winston Ndugu and newcomer Dr Monica Beltran, while Dr Mika Yasuda and Dr Jules Millin shared a near-kiss. Where will things go next? Well, given Yasuda's coming exit, it can't be good...

Is there a trailer for Grey's Anatomy season 21?

There is – and it certainly seems as though it's all out war at Grey Sloan Memorial!

Watch the trailer for yourself below.

Grey's Anatomy seasons 1 to 20 are available to stream on Disney Plus now – sign up to Disney Plus for £7.99 a month or £79.90 a year now. Season 18 is also available on Sky and NOW with new episodes airing on Sky Witness in the UK.

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Lewis KnightTrends Editor

Lewis Knight is the Trends Editor for Radio Times, covering trending titles from TV, Film and more. He previously worked at The Mirror in TV, Film, and Showbiz coverage alongside work on SEO. Alongside his past work in advertising, he possesses a BSc in Psychology and an MA in Film Studies.

Morgan Cormack
Morgan CormackDrama Writer

Morgan Cormack is a Drama Writer for Radio Times, covering everything drama-related on TV and streaming. She previously worked at Stylist as an Entertainment Writer. Alongside her past work in content marketing and as a freelancer, she possesses a BA in English Literature.

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