The synopsis reads: "Jo is approached by a gang who know all about her son and is blackmailed into using her job to smuggle drugs.
"She soon finds herself pulled into a murky underworld of corrupt cops and hired killers, forced to carry out their orders with no escape in sight.
"However, no matter how far Jo finds herself from her old life, her mission remains the same, to keep her son alive."
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In Flight is a six-episode series co-created and written by Mike Walden (Marcella) and Adam Randall (Slow Horses), while Chris Baugh (BBC Three's Wreck) is handling directing duties. It does not yet have a premiere date on Channel 4.
Katherine Kelly said: "I am really excited to be taking on the role of Jo and I can’t wait to tell her compelling story. I am delighted to be working with Buccaneer Media again and it’s joy to be filming in Belfast."
The cast of In Flight also includes Stuart Martin (Rebel Moon), Ashley Thomas (Great Expectations), Bronagh Waugh (Ridley), Harry Cadby (Everything Now), Corinna Brown (Heartstopper) and Ambreen Razia (Ted Lasso).
Co-creators Walden and Randall commented: "In Flight is our spin on the noir genre, a high stakes, stylish, romantic thriller with iconic characters and nerve shredding action.
"Channel 4 is the perfect home for our story and we're so excited to be collaborating with such a brilliant team. Jo is a character close to our hearts. She is an ordinary woman facing extraordinary odds. We can't wait for audiences to meet her."
In Flight is coming soon to Channel 4.
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